We tested the relationship between transformational leadership and stress responses by using a two- dimensional stressor framework. Results of a cross-sectional questionnaire (N = 318) showed that transformational leadership had a direct negative effect on stress responses. Meanwhile, transformational leadership had a positive relationship with challenge stressors, and a negative relationship with hindrance stressors. The positive relationship with challenge stressors had a positive effect on promoting work satisfaction, and gave meaning to the work of followers, however it also had a positive relationship with stress responses, which is a point that is usually ignored.